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NIS Database Documentation The Nationwide Inpatient Sample (NIS) is the largest all-payer inpatient care database in the United States, containing data on more than seven million The increasing incidence of newborn circumcision: data from the MATERIALS AND METHODS: The Nationwide Inpatient Sample provides information on 5 million to 7 million inpatient stays per year. Mortality of stroke patients treated with thrombolysis: Analysis The authors performed a retrospective cohort comparison using the Nationwide Inpatient Sample for 1999 through 2002 of acute ischemic stroke admissions. TrueData" 1 Weighted national estimates from HCUP Nationwide Inpatient Sample (NIS), based on data collected by individual states and provided by the states.